Multimorbidity and Complexity Research Group


Multimorbidität und Polypharmazie und der Einfluss auf die Ernährung

Fischer. K., Battegay, E., Holzer, B.M

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We conduct interdisciplinary research to support clinical and nonclinical decision makers involved in the management of multimorbid patients.

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Our research combines the knowledge and perspectives of medical clinicians, data scientists, psychologists, and engineers from biomedicine, computer graphics and computer linguistics.

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We aim to provide knowledge and tools to aid decision making in multimorbidity management, complexity, uncertainty and risk.

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Who is multimorbid

Individuals with complex interactions between multiple acute and chronic medical conditions.

Scale of multimorbidity

20–30% of the Swiss population and ca. 80% of patients in city hospitals are multimorbid.

Impact of multimorbidity

Multimorbidity can place a very heavy burden on patients, lead to high utilization of health service resources, and generate substantial health care costs.

Clinical Management

Depending on the severity and complexity of multiple conditions, a patient's unique combination of diseases and treatment options, benefits and risks needs to be carefully managed.


Main Research Areas

We have two complementary areas of research that use different data sources and methods.

Multimorbidity Health Analytics

We apply data scientific methods such as machine learning, visual analytics and medical informatics to healthcare data that is accumulated during healthcare delivery of hospitalized patients.

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Health Decision Science

We focus on clinical decision-making, risk assessment and communication under real world conditions of complexity, uncertainty and competing demands in the clinical management of multimorbid patients.

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These areas of research enable us to generate clinically meaningful insights and knowledge about multimorbidity and its clinical management from different perspectives. They also provide real world evidence with which to identify opportunities and test ways to improve management of multimorbid patients.


Management of hyperglycaemia in persons with non-insulin-dependent type 2 diabetes mellitus

Tatalovic, M., Lehmann, R., Cheetham, M.


Long-Term Outcomes of Kidney Transplantation in Fabry Disease

Ersözlü, S., Huynh-Do, U., Canaan-Kühl, S., et al.


Mehrfach komplex erkrankt: Welche Weichenstellungen sind für eine gute Versorgung nötig?

Battegay, E., und Zeltner, T


Multimorbidität und Polypharmazie und der Einfluss auf die Ernährung

Fischer. K., Battegay, E., Holzer, B.M.


What makes internal medicine attractive for the millennial generation?

Cribari, M., Holzer, B.M., Battegay, E., et al.


Assessing adherence to multiple medications and in daily life among patients with multimorbidity

Inauen, J., Bierbauer W, Lüscher J, et al.


Choosing Wisely – An international and multimorbid perspective

Battegay E., Cheetham, M.


Chronic Pain: How Challenging Are DDIs in the Analgesic Treatment of Inpatients with Multiple Chronic Conditions?

Siebenhuener, K., Eschmann, E., Kienast, A., et al.


Evidence-based design recommendations for prevalence studies on multimorbidity: improving comparability of estimates

Holzer, B. M., Siebenhuener, K., Bopp, M., & Minder, C. E.


Health Behavior Change in Older Adults

Bierbauer, W., Inauen, J., Schaefer, S., et al.


Multimorbiditätsmanagement im Alltagsdilemma

Battegay E., Cheetham, M., Holzer, B.M., et al.


The frequent and underrecognised co-occurrence of acute exacerbated COPD and depression warrants screening: a systematic review

Lecheler, L., Richter, M., Franzen, D.P., et al.


The Multimorbidity Interaction Severity Index (MISI): A proof of concept study

Gassmann, D., Cheetham, M., Siebenhüner, K., et al.


Zunehmende Multimorbidität im Krankheitsspektrum einer alternden Gesellschaft

Holzer, B.M., und Saller, R.


Determinants of diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin

Pereira, A.M., Husmann, L., Sah, B.R., et al.


Multimorbide Patienten: mehrfach erkrankt, mehrfach therapiert. Eine Herausforderung durch Interaktionen

Siebenhuener, K., Meindl-Fridez, C., Holzer, B.M., et al.


Navigating the geography of mortality--towards a GPS for Public Health Policy

Battegay, E.


Prospective and retrospective memory are differentially related to self-rated omission and commission errors in medication adherence in multimorbidity

Ihle, A., Inauen, J., Scholz, U., et al.


Tracing the decision-making process of physicians with a Decision Process Matrix

Hausmann, D., Zulian, C., Battegay, E., et al.


Gastrointestinal bleeding and anticoagulant or antiplatelet drugs: systemtatic search for clinical practice guidelines

Gutermann, I.K., Niggemeier, V., Zimmerli, L.U., et al.


Editorial: Quality of life in multimorbidity

Martin, M., Battegay, E., Röcke, C


Multimorbidity and Quality of Preventive Care in Swiss University Primary Care Cohorts

Streit, S., da Costa, B.R., Bauer, D.C., et al.


Overcoming cut-off restrictions in multimorbidity prevalence estimates

Holzer, B.M., Siebenhuener, K., Bopp, M., et al.


Therapeutic conflicts in emergency department patients with multimorbidity: a cross-sectional study

Markun, S., Holzer, B.M., Rodak, R., et al.


Age- and gender-related prevalence of multimorbidity in primary care

Rizza, A., Kaplan, V., Senn, O., et al.


Multimorbidity and chronic diseases increasingly shape the daily routine of physicians

Battegay, E.


The better the medicine, the more chronic and multiple morbidity patients....?

Battegay, E.


Prevalence of multimorbidity in medical inpatients

Schneider, F., Kaplan, V., Rodak, R., et al.